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. 2017 Jul 12;174(16):2784–2796. doi: 10.1111/bph.13904

Figure 9.

Figure 9

Compartmentalized cAMP signalling in human ASM cells. EP2 receptor stimulation of AC2 in non‐lipid raft domains of the plasma membrane produces cAMP that can be detected by Epac2‐CAAX, Epac2‐NLS and Epac2‐camps biosensors. β2‐adrenoceptor (AR) stimulation of AC6 in lipid raft domains of the plasma membrane produces cAMP that can be detected by Epac2‐MyrPalm, Epac2‐camps, Epac2‐NLS and Epac2‐CAAX biosensors.