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Lack of effect of the β2‐adrenoceptor antagonist ICI 118,551 on the cardiodepressant effects of mirabegron in the presence of the β1‐adrenoceptor antagonist CGP 20712A. (A) Representative recordings of mirabegron (10 μM) in the presence of CGP 20712A 300 nM (top recording) and CGP 20712A 300 nM + ICI 118,551 50 nM (bottom recording) in trabeculae from a 55 year female patient with aortic valve disease. (B) Bar graph shows summary of data; numbers in brackets are trabeculae/patients.
