Figure 8.
(A) IEGs mRNA expression in the nucleus accumbens from WT and SERT Met172 chronically treated with cocaine (15 mg·kg−1, i.p.) or saline (20 mL·kg−1) followed by 14 days of abstinence and a challenge dose (cocaine 15 mg·kg−1 or saline). Mice were killed 120 min after the challenge dose. Main interaction for Egr1 and main treatment effect for all genes except for Egr2; two‐way ANOVA Data are mean ± SEM.; n = 8–9; exact group sizes are indicated in the graphs. * P < 0.05, signficantly different as indicated; Sidak post hoc test. (B) IEGs expression in the prelimbic cortex from mice challenged with a cocaine or saline dose after 14 days abstinence as described in A. Main treatment effect for Fosb, Junb, Egr1 and Arc, two‐way ANOVA. Data are mean ± SEM; n = 8–9; exact group sizes are indicated in the graphs. *P < 0.05, signficantly different as indicated; Sidak post hoc test.