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. Author manuscript; available in PMC: 2018 Jun 6.
Published in final edited form as: Circulation. 2017 Mar 29;135(23):2288–2298. doi: 10.1161/CIRCULATIONAHA.116.025390

Fig. 2. VEGFR3 and BMPR2 co-internalize upon ligand stimulation.

Fig. 2

(A) Biotinylation assay showing internalization of surface BMPR2 in response to BMP6 stimulation in a time dependent manner. (B) Inhibition of Dynamin-dependent endocytosis decreases phosphorylation of SMAD 1/5. (C) Stimulation with BMP6 induces internalization of VEGFR3 and BMPR2 in both HUVECs and PAECs in a time dependent manner. (D) Lack of VEGFR3 in HUVECs abrogated ligand-dependent internalization of BMPR2 in HUVECs.