Table 1.
Clinical characteristics of the enrolled subjects
| Characteristic | Blood | Liver biopsy tissue | ||||
|---|---|---|---|---|---|---|
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| HC | LC | CHB | HC | LC | CHB | |
| Case | 10 | 10 | 64 | 7 | 4 | 43 |
| Age (years) | 29 ± 5 | 44 ± 8 | 42 ± 6 | 27 ± 10 | 42 ± 7 | 41 ± 21 |
| Sex (male/female) | 5/5 | 7/3 | 46/18 | 2/5 | 3/1 | 30/13 |
| Baseline ALT (U/l) | ND | 55.0 ± 18.0 | 606.5 ± 593.5 | ND | 42.0 ± 26.0 | 606.0 ± 594.0 |
| Baseline AST (U/l) | ND | 47.0 ± 21 | 194.5 ± 172.5 | ND | 38.0 ± 22.0 | 697.0 ± 681.0 |
| Log10 baseline HBV DNA (IU/ml) | ND | 5.31 ± 1.65 | 7.1 ± 2.39 | ND | 6.31 ± 2.64 | 6.22 ± 2.73 |
| Baseline serum HBsAg (IU/ml) | ND | ND | 4.68 ± 4.62 | ND | ND | 4.68 ± 4.62 |
| Baseline serum IP-10 (pg/ml) | ND | ND | 866.03 ± 756.41 | ND | ND | 844.69 ± 795.48 |
| Intrahepatic IP-10 mRNA (lg cDNA) | ND | ND | ND | −2.18 ± 1.06 | −1.8 ± 0.21 | −1.48 ± 0.96 |
Abbreviations: HC, healthy controls; LC, liver cirrhosis; CHB, chronic hepatitis B; ALT, alanine ransaminase; AST, aspartate transaminase; HBsAg, hepatitis B surface antigen; IP-10, interferon (IFN)-γ-induced protein 10; ND, not detected. Data are shown as numbers ± s.d.