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Combination index values obtained in breast cancer cells exposed to different drug combinations schemes. SUM-229PE and SK-BR-3 cells were incubated with drug combinations of vitamin D derivative: lapatinib (A) or neratinib (B); 20:20 (●); 20:50 (○); 50:20 (▼); and 50:50 (Δ). The combination index was calculated with the equation of Chou and Talalay. The data points below combination index values of 1 denoted by a horizontal line on each plot are indicative of synergistic interactions.
