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Inhibitory concentration (IC)20 and 50 values of lapatinib and neratinib on breast cancer cells proliferation
| Compound | IC | SUM-229PE (mol/L) | SK-BR-3 (mol/L) | HCC1937 (mol/L) |
|---|---|---|---|---|
| Lapatinib | 20 | 1.3 × 10-7 | 1.6 × 10-8 | 4.5 × 10-8 |
| 50 | 3.5 × 10-7 | 8.9 × 10-8 | 6.0 × 10-6 | |
| Neratinib | 20 | 6.7 × 10-9 | 8.1 × 10-10 | 8.5 × 10-8 |
| 50 | 1.4 × 10-8 | 2.1 × 10-9 | 7.5 × 10-7 | |
| Calcitriol (23) | 20 | 4.6 × 10-9 | 4.6 × 10-10 | - |
| 50 | 1.4 × 10-8 | 2.4 × 10-9 | - | |
| EB1089 (23) | 20 | 2.0 × 10-10 | 4.3 × 10-10 | - |
| 50 | 2.7 × 10-9 | 7.5 × 10-10 | - |
