Table 2.
Mutation pathway enrichment
| Category | Term | Count | % | P-value | Benjamini | genes |
|---|---|---|---|---|---|---|
| KEGG | Adherens junction | 8 | 21.6 | 1.30E-07 | 1.30E-06 | CREBBP EP300 CDH1 CTNNB1 EGFR MET TGFBR2 ERBB2 |
| KEGG | Focal adhesion | 7 | 18.9 | 6.40E-04 | 3.40E-03 | CTNNB1 EGFR MET PTEN PIK3CA ERBB2 BRAF |
| KEGG | ErbB signaling pathway | 5 | 13.5 | 1.20E-03 | 5.50E-03 | EGFR PIK3CA KRAS ERBB2 BRAF |
| KEGG | MAPK signaling pathway | 7 | 18.9 | 2.80E-03 | 1.20E-02 | EGFR FGFR3 NF1 TGFBR2 TP53 KRAS BRAF |
| KEGG | Regulation of actin cytoskeleton | 6 | 16.2 | 5.70E-03 | 2.40E-02 | APC EGFR FGFR3 PIK3CA KRAS BRAF |
| AKEGG | Jak-STAT signaling pathway | 5 | 13.5 | 9.60E-03 | 3.30E-02 | CREBBP EP300 JAK2 JAK3 PIK3CA |
| PANTHER | P00059: p53 pathway | 7 | 18.9 | 4.50E-04 | 1.20E-02 | CREBBP EP300 MYST4 PTEN PIK3CA ATM TP53 |
| PANTHER | P00057: Wnt signaling pathway | 9 | 24.3 | 5.60E-03 | 7.10E-02 | ARID1A CREBBP EP300 MYST4 APC CDH1 CTNNB1 GNAQ TP53 |
| PANTHER | P00018: EGF receptor signaling pathway | 6 | 16.2 | 6.50E-03 | 6.70E-02 | EGFR PIK3CA ATM KRAS ERBB2 BRAF |
| PANTHER | P00005: Angiogenesis | 7 | 18.9 | 1.00E-02 | 8.80E-02 | NOTCH1 APC CTNNB1 FGFR3 PIK3CA KRAS BRAF |
| PANTHER | P00031: Inflammation mediated by chemokine and cytokine signaling pathway | 8 | 21.6 | 1.30E-02 | 9.30E-02 | JAK2 JAK3 GNAQ MYH11 PTEN PIK3CA KRAS BRAF |
| PANTHER | P00048: PI3 kinase pathway | 5 | 13.5 | 1.60E-02 | 1.00E-01 | JAK2 GNAQ PTEN PIK3CA KRAS |
| PANTHER | P00052: TGF-beta signaling pathway | 5 | 13.5 | 4.20E-02 | 2.00E-01 | CREBBP EP300 MYST4 TGFBR2 KRAS |
| PANTHER | P00047: PDGF signaling pathway | 5 | 13.5 | 6.90E-02 | 2.90E-01 | JAK2 JAK3 PIK3CA KRAS BRAF |
| BIOCARTA | TGF beta signaling pathway | 5 | 13.5 | 8.60E-05 | 9.90E-03 | CREBBP EP300 APC CDH1 TGFBR2 |