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. 2017 May 22;6(5):e339. doi: 10.1038/oncsis.2017.31

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Copyright © 2017 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Sp1 induces CYP17A1 overexpression by inhibiting DNMT3a-mediated DNA methylation, thus resulting in an increase in DHEA biosynthesis and glioma resistance to TMZ.