Figure 8.

Androgen signalling inhibits PHB-mediated E2F1 repression, leading to cell cycle progression. Schematic of proposed mechanism for PHB and AR interaction at G1. Ligand binding to the AR leads to intracellular signalling cascades emanating from Src phosphorylation, leading to PHB:E2F1 disruption and dissociation of PHB from chromatin. PHB may be potentially dephosphorylated, while E2F1 and Rb are phosphorylated. E2F1 then goes onto stimulate transcription of genes required for S-phase entry, for example, MCM2-5, DNA polymerases and nucleotide biosynthesis gene, for example, TK1.