Table 3. Extracellular proteins whose expression were significantly affected by Trpv4-gene silencing alone.

TRPV4-specific protein expression affected by Trpv4-gene silencing	Mode of secretion	MW (kDa)	% Coverage	Fold change S1_DMSO: Luc_DMSO	P-value	Fold change S3_DMSO: Luc_DMSO	P-value
Gene_Symbol=Cdk5 Cell division protein kinase 5	Exosome	33	45.55	0.59	5.17E−16	0.72	1.09E−14
Gene_Symbol=Ube2l3 Ubiquitin-conjugating enzyme E2 L3	Exosome	17	42.86	0.71	0.01	0.64	2.56E−4.0
Gene_Symbol=Pcf11 Cleavage and polyadenylation factor subunit homolog	Exosome	173	27.88	1.67	0.01	1.40	4.28E−5.0
Gene_Symbol=Nefm Neurofilament medium polypeptide	Exosome	160	44.10	1.39	0.03	1.30	4.09E−3.0