Table 7.
Performance of cutoff values and combinations of the biomarkers IL-6, IL-8, IL-10, and PCT (all in pg/mL) as sepsis discriminators on day 1 of fever, compared with the high-risk assessment model. S = sensitivity; E = specificity; PPV = positive predictive value; NPV = negative predictive value; LR+ = positive likelihood ratio; LR− = negative likelihood ratio.
| IL-6 > 170 | IL-8 > 240 | PCT > 180 | IL-10 > 6 | High risk | |
|---|---|---|---|---|---|
| S | 0.69 | 0.69 | 0.80 | 0.69 | 1.00 |
| E | 0.95 | 1.00 | 0.68 | 0.86 | 0.44 |
| PPV | 0.90 | 1.00 | 0.50 | 0.75 | 0.42 |
| NPV | 0.84 | 0.85 | 0.89 | 0.83 | 1.00 |
| LR+ | 9.00 | − | 1.00 | 3.00 | 0.71 |
| LR− | 0.19 | 0.18 | 0.12 | 0.21 | 0.00 |
| Youden J | 0.65 | 0.69 | 0.48 | 0.56 | 0.44 |
|
| |||||
| IL-8 > 240 + high risk | PCT > 180 + high risk | IL-10 > 6 + PCT > 180 | IL-8 > 100 + PCT > 100 | IL-6 > 50 + PCT > 100 | |
|
| |||||
| S | 0.69 | 0.77 | 0.69 | 0.85 | 0.85 |
| E | 1.00 | 0.86 | 0.91 | 0.91 | 0.82 |
| PPV | 1.00 | 0.77 | 0.82 | 0.85 | 0.73 |
| NPV | 0.85 | 0.86 | 0.83 | 0.91 | 0.90 |
| LR+ | — | 3.33 | 4.50 | 5.50 | 2.75 |
| LR− | 0.18 | 0.16 | 0.20 | 0.10 | 0.11 |
| Youden J | 0.69 | 0.63 | 0.60 | 0.76 | 0.66 |