Figure 5.
Conseqences of replicative homeostatic cycles. Disturbance to intracellular replicative homeostatic cycles. Events increasing intracellular EnvWt: Envmt ratio (exogenous addition of EnvWt, antibody recognition of Envmt) will favour EnvWt:RNApol interactions, increasing RNApol processivity and reducing fidelity increasing relative output of variant virus. Conversely, events decreasing intracellular EnvWt: Envmt ratios (exogenous addition of Envmt, antibody recognition of EnvWt) will favour Envmt:RNApol interactions, decreasing RNApol processivity and increasing fidelity, thus reducing replication.