Figure 2.
Curc-mPEG454 reduced hepatic steatosis and hepatic lipid levels after 16-week treatment. Compared with the livers in the chow group, HFD-induced typical steatosis was evidenced by H&E staining (a) and oil red O staining (b) of lipids in representative liver section; a test system containing 36 test points was superimposed on HE-stained images, and the degree of steatosis was assessed by point counting (c), the degree of steatosis of each group (d), and the content of liver TG (e). Curc-mPEG454 treatment significantly reversed the changes. Quantified date are mean ± SD. ∗∗∗P < 0.001 versus chow group; ##P < 0.01 and ###P < 0.001 versus HFD group.
