Table 2.

Effect of Curc-mPEG454 on body, liver weight, serum lipids, ALT, and AST in high-fat-diet-fed mice.

Group	Chow	HFD	HFD + Curc-mPEG454 50	HFD + Curc-mPEG454 100
Original body weight (g)	21.30 ± 1.16	21.13 ± 0.99	21.38 ± 1.19	20.55 ± 1.01
Final body weight (g)	30.81 ± 2.06	44.08 ± 5.44∗∗	37.64 ± 3.13#	37.67 ± 4.36#
Body weight gain (g)	9.51 ± 2.45	22.95 ± 5.14∗∗	16.26 ± 3.42#	17.12 ± 4.56#
Liver weight (g)	1.06 ± 0.09	1.43 ± 0.28∗	1.35 ± 0.21	1.27 ± 0.19
Serum TG (mmol/L)	0.67 ± 0.05	0.84 ± 0.06∗	0.63 ± 0.12##	0.61 ± 0.06##
Serum TC (mmol/L)	2.82 ± 0.06	4.17 ± 0.52∗	3.72 ± 0.85	3.44 ± 0.87
Serum HDL-C (mmol/L)	1.22 ± 0.07	1.77 ± 0.19∗	1.68 ± 0.24∗	1.66 ± 0.36#
Serum LDL-C (mmol/L)	0.39 ± 0.06	0.41 ± 0.06	0.32 ± 0.08	0.28 ± 0.09#
Serum FFA level (mmol/L)	1.05 ± 0.15	1.07 ± 0.13	1.03 ± 0.14	1.19 ± 0.16
Serum ALT level (mmol/L)	53.75 ± 8.57	55.25 ± 10.9	40.25 ± 12.66	43.75 ± 9.43
Serum AST level (mmol/L)	128.25 ± 17.80	128.75 ± 19.98	121.00 ± 18.65	112.00 ± 13.14

Body weight gain was calculated by the difference between final body weight at the end of the experiments and original body weight. Data are expressed as mean ± SD. ^∗P < 0.05 versus chow and ^∗∗P < 0.01 versus chow; ^#P < 0.05 versus HFD and ^##P < 0.01 versus HFD.