Table 1.
BDNF improved cardiac function in septic shock rats that was reduced by L-NAME.
| Group | HR (beats/min) | MABP (mmHg) | LV dP/dtmax (mmHg/s) |
LV dP/dtmin (mmHg/s) |
LVEDP (mmHg) | LVSP (mmHg) |
|---|---|---|---|---|---|---|
| Sham | 430 ± 52 | 110.52 ± 12.64 | 6682 ± 646 | −4818 ± 356 | 11.22 ± 4.86 | 130.24 ± 11.46 |
| CLP | 460 ± 42 | 68.46 ± 15.38∗ | 3980 ± 386∗ | −2860 ± 246∗ | 19.82 ± 5.02∗ | 89.74 ± 9.12∗ |
| CLP + BDNF | 446 ± 54 | 96.86 ± 12.12# | 6024 ± 562# | −4328 ± 302# | 13.02 ± 4.06# | 124.68 ± 12.48# |
| CLP + BDNF + L-NAME | 458 ± 50 | 70.02 ± 10.46& | 4126 ± 428& | −3022 ± 286& | 18.98 ± 5.82& | 94.56 ± 10.06& |
HR: heart rate; MABP: mean arterial blood pressure; LV dP/dtmax: left ventricular (LV) maximal pressure development; LV dP/dtmin: left ventricular (LV) minimal pressure development; LVEDP: left ventricular end-diastolic pressure; LVSP: left ventricular systolic pressure. Data are mean ± SEM. ∗P < 0.05 versus control group, #P < 0.05 versus CLP group, &P < 0.05 versus CLP + rhBDNF. CLP: cecal ligation and puncture; rhBDNF: recombined BDNF protein.