Table 1.
Demographics and clinical characteristics of the subject groups
| 1A Cohort Comparison
| |||
|---|---|---|---|
| Demographics
|
Statistic | ||
| Bipolar-Manic Subjects (n=26) | Bipolar-Euthymic Subjects (n=21) | Mania vs Euthymia | |
| Sex | 20 Male, 6 Female | 13 Male, 8 Female | p=.263 |
| Age in years, mean (SD) | 27.7 (10.5) | 33 (12.9) | p=.094 |
| # of hospitalizations, mean (SD) | 3.79 (4.19) | 4.61 (3.8) | p=.423 |
| Duration of illness in years, mean (SD) | 11.6 (12.1) | 7.32 (7) | p=.308 |
| YMRS, mean (SD) | 28.6 (6.71) | 3.62 (3.84) | p= 4.75 × 10-9 |
| MADRS, mean (SD) | 14.3 (8.03) | 6.09 (5.48) | p = 2.54×10-4 |
| PANSS, mean (SD) | 56 (16.2) | 39 (8.85) | p=2.21 × 10-4 |
| PANSS positive subscale, mean (SD) | 22.7 (5.35) | 9.9 (3.51) | p=2×10-8 |
| Anticonvulsants | 8/26 | 10/21 | ns |
| Antipsychotics | 25/26 | 16/21 | p=.041 |
| CPZ equivalents, mean (SD) | 396 (349) | 203 (239) | p=0.014 |
| Benzodiazepines | 8/26 | 4/21 | ns |
| Lithium | 18/26 | 8/21 | p=.033 |
| Antidepressants | 1/26 | 3/21 | ns |
| 1B Longitudinal Comparison
| ||||
|---|---|---|---|---|
| Bipolar Subjects (n=10) | HC subjects (n=10) | |||
| Sex | 6 Male, 4 Female | 5 Male, 5 Female | ||
| Age in years at first scan, mean (SD) | 25.6 (8.90) | 27.8 (13.2) | ||
| # of hospitalizations, mean (SD) | 3.2 (2.3) | n/a | ||
| Duration of illness in years, mean (SD) | 6.1 (5.61) | n/a | ||
| Time in months Between Scans, mean (SD) | 15.2 (14.7) | 19.7 (18.9) | ||
| State | Statistic | |||
| Mania | Euthymia | Mania vs Euthymia | ||
| YMRS, mean (SD) | 26.7 (3.68) | 2 (2.31) | p= 9.93×10-9 | |
| MADRS, mean (SD) | 14.5 (11.9) | 3.2 (3.19) | p= 0.01 | |
| PANSS, mean (SD) | 58.9 (11.05) | 33.2 (6.01) | p= 7.81×10-6 | |
| PANSS positive subscale, mean (SD) | 23.2 (5.53) | 7.7 (1.06) | p= 8.48×10-6 | |
| Anticonvulsants | 6/10 | 5/10 | ns | |
| Antipsychotics | 9/10 | 7/10 | ns | |
| CPZ equivalents, mean (SD) | 364(227) | 262(382) | ns | |
| Benzodiazepines | 3/10 | 1/10 | ns | |
| Lithium | 8/10 | 8/10 | ns | |
| Antidepressants | 0/10 | 1/10 | ns | |
Abbreviations: CPZE: Chlorpromazine equivalents, MADRS: Montgomery-Asberg Depression Rating Scale, ns: non-significant, PANSS: Positive And Negative Symptom Scale, SD: Standard Deviation, YMRS: Young Mania Rating Scale