Table 2.
Mean average (mean ± SD) of rats’ testes parameters in treated groups
| Testis parameters | Control | CDDP | CDDP + PTX (75mg/Kg) | CDDP + PTX (150mg/kg) | CDDP + PTX (300mg/kg) | PTX (150mg/kg) | PTX (300mg/kg) |
|---|---|---|---|---|---|---|---|
| Left testis weight (g) | 1.53 ± 0.02 | 1.25 ± 0.06* | 1.34 ± 0.03 | 1.35 ± 0.04 | 1.20 ± 0.08*# | 1.48 ± 0.11 | 1.49 ± 0.02 |
| Right testis weight (g) | 1.51 ± 0.03 | 1.24 ± 0.05* | 1.37 ± 0.04 | 1.33 ± 0.06 | 1.23 ± 0.09 | 1.47 ± 0.12 | 1.49 ± 0.01 |
| Seminiferous tubule diameter (μm) | 268.63 ± 13.49 | 330.08 ± 28.80 | 267.95 ± 12.06 | 296.95 ± 21.06 | 275.09 ± 14.16 | 258.63 ± 11.49 | 251.94 ± 10.07 |
| Germinal cell layer (μm) | 262.69 ± 14.22 | 73.24 ± 6.67*** | 57.88 ± 3.64***# | 68.20 ± 6.35*** | 82.83 ± 6.33*** | 48.03 ± 5.49***# | 54.6 ± 4.02***# |
| Spermatogonia cell number (mm2) | 84.5 ± 4.23 | 115.25 ± 3.24** | 108.58 ± 6.78** | 116.33 ± 3.85** | 156.33 ± 13.59**# | 140.01 ± 8.49**# | 139.83 ± 11.41**# |
| Leydig cell (mm2) | 5.33 ± 0.61 | 5.33 ± 0.37 | 5.25 ± 0.39 | 5.17 ± 0.45 | 5.01 ± 0.36 | 5.01 ± 0.49 | 4.5 ± 0.33 |
| Sertoli cell (mm2) | 4.02 ± 0.36 | 4.5 ± 0.31 | 3.75 ± 0.21# | 5.24 ± 0.31 | 4.33 ± 0.28# | 4.02 ± 0.38 | 4.02 ± 0.27 |
*
p<0.05,
**
p<0.01,
***
p<0.001 compared to control;
#
p<0.05 compared to CDDP-treated group.