Table 11.
Oxidative stress analysis of rat lung treated with nano-sized Nd2O3 for 28 days
| Parameter (after 28-day exposure) | Dose (mg/m3) | |||
|---|---|---|---|---|
|
| ||||
| 0 | 0.5 | 2.5 | 10 | |
| No. of animals examined | 8 | 8 | 8 | 8 |
| GSH (nmol/mg protein) | 1.97 ± 0.55a | 1.34 ± 0.90 | 0.69 ± 0.25** | 0.48 ± 0.22** |
| Catalase (units/mg protein) | 35.5 ± 8.82 | 22.3 ± 2.37* | 26.6 ± 7.95 | 38.3 ± 4.59 |
|
| ||||
| Parameter (after 28-day recovery) | Dose (mg/m3) | |||
|
| ||||
| 0 | 0.5 | 2.5 | 10 | |
|
| ||||
| No. of animals examined | 8 | 8 | 7 | 8 |
| GSH (nmol/mg protein) | 1.49 ± 0.59 | 1.16 ± 0.20 | 1.05 ± 0.19 | 0.55 ± 0.30* |
| Catalase (units/mg protein) | 31.6 ± 7.99 | 28.9 ± 4.03 | 37.0 ± 4.18 | 33.0 ± 6.83 |
GSH, glutathione.
a
Values are expressed as means ± SD.
*,**
Significantly different from vehicle control at p<0.05 and p<0.01.