Table 8.
Parameter (after exposure) | Dose (mg/m3) | |||
---|---|---|---|---|
| ||||
0 | 0.5 | 2.5 | 10 | |
No. of animals examined | 8 | 8 | 8 | 8 |
Body weight (g) | 346.3 ± 18.53a | 345.4 ± 21.98 | 359.2 ± 19.99 | 347.1 ± 19.53 |
Lung (g) | 1.391 ± 0.094 | 2.141 ± 0.270** | 2.345 ± 0.114** | 2.238 ± 0.149** |
Per body weight (%) | 0.402 ± 0.016 | 0.619 ± 0.059** | 0.655 ± 0.047** | 0.645 ± 0.034** |
Liver (g) | 9.395 ± 0.664 | 9.490 ± 0.867 | 9.843 ± 0.981 | 9.189 ± 0.585 |
Per body weight (%) | 2.713 ± 0.110 | 2.745 ± 0.124 | 2.735 ± 0.155 | 2.650 ± 0.149 |
Kidney (g) | 2.325 ± 0.161 | 2.424 ± 0.142 | 2.456 ± 0.218 | 2.345 ± 0.118 |
Per body weight (%) | 0.672 ± 0.043 | 0.703 ± 0.043 | 0.683 ± 0.040 | 0.676 ± 0.032 |
Spleen (g) | 0.651 ± 0.085 | 0.644 ± 0.060 | 0.657 ± 0.070 | 0.610 ± 0.072 |
Per body weight (%) | 0.188 ± 0.018 | 0.186 ± 0.011 | 0.183 ± 0.014 | 0.176 ± 0.021 |
Brain (g) | 2.038 ± 0.084 | 2.006 ± 0.049 | 2.044 ± 0.094 | 1.981 ± 0.086 |
Per body weight (%) | 0.590 ± 0.033 | 0.583 ± 0.038 | 0.571 ± 0.041 | 0.572 ± 0.035 |
| ||||
Parameter (after recovery) | Dose (mg/m3) | |||
| ||||
0 | 0.5 | 2.5 | 10 | |
| ||||
No. of animals examined | 8 | 8 | 7 | 8 |
Body weight (g) | 499.9 ± 28.93 | 495.9 ± 25.25 | 464.6 ± 44.10 | 488.6 ± 30.07 |
Lung (g) | 1.709 ± 0.132 | 2.118 ± 0.191** | 3.077 ± 0.482** | 3.495 ± 0.460** |
Per body weight (%) | 0.342 ± 0.027 | 0.427 ± 0.030** | 0.661 ± 0.063** | 0.716 ± 0.082** |
Liver (g) | 13.75 ± 1.675 | 13.49 ± 0.918 | 12.39 ± 1.509 | 13.02 ± 1.021 |
Per body weight (%) | 2.745 ± 0.224 | 2.720 ± 0.144 | 2.664 ± 0.135 | 2.667 ± 0.151 |
Kidney (g) | 3.071 ± 0.292 | 2.974 ± 0.173 | 2.829 ± 0.357 | 2.890 ± 0.148 |
Per body weight (%) | 0.614 ± 0.033 | 0.600 ± 0.033 | 0.610 ± 0.058 | 0.592 ± 0.029 |
Spleen (g) | 0.926 ± 0.095 | 0.862 ± 0.116 | 0.828 ± 0.080 | 0.853 ± 0.034 |
Per body weight (%) | 0.185 ± 0.017 | 0.174 ± 0.021 | 0.178 ± 0.010 | 0.175 ± 0.013 |
Brain (g) | 2.140 ± 0.098 | 2.113 ± 0.055 | 2.073 ± 0.072 | 2.066 ± 0.099 |
Per body weight (%) | 0.428 ± 0.014 | 0.427 ± 0.018 | 0.450 ± 0.049 | 0.425 ± 0.041 |
Values are expressed as means ± SD.
Significantly different from vehicle control at p<0.01.