Table 9.
Histopathologic findings of rats treated with nano-sized Nd2O3 for 28 days
| Organ/Findings (after exposure) | Grade | Dose (mg/m3) | |||
|---|---|---|---|---|---|
|
| |||||
| 0 | 0.5 | 2.5 | 10 | ||
| No. of animals examined | 8 | 8 | 8 | 8 | |
| Normal appearance | 6 | 0 | 0 | 0 | |
| Lung | |||||
| Alveolar proteinosis | ± | 0 | 7 | 7 | 6 |
| + | 0 | 1 | 1 | 1 | |
| ++ | 0 | 0 | 0 | 1 | |
| Hyperplasia/hypertrophy, alveolar type II cells | ± | 0 | 1 | 0 | 1 |
| Aggregation, alveolar macrophages | ± | 0 | 2 | 0 | 1 |
| + | 0 | 3 | 0 | 0 | |
| Infiltration, inflammatory cells, alveolar/perivascular | ± | 2 | 3 | 5 | 2 |
| + | 0 | 0 | 0 | 1 | |
| ++ | 0 | 0 | 0 | 1 | |
| Lymph node, hilar | |||||
| Aggregation, macrophages | ± | 0 | 1 | 0 | 1 |
| + | 0 | 0 | 0 | 1 | |
|
| |||||
| Organ/Findings (after recovery) | Grade | Dose (mg/m3) | |||
|
| |||||
| 0 | 0.5 | 2.5 | 10 | ||
|
| |||||
| No. of animals examined | 8 | 8 | 7 | 8 | |
| Normal appearance | 5 | 1 | 0 | 0 | |
| Lung | |||||
| Alveolar proteinosis | ± | 0 | 6 | 5 | 0 |
| + | 0 | 0 | 1 | 6 | |
| ++ | 0 | 0 | 0 | 2 | |
| +++ | 0 | 0 | 1 | 0 | |
| Hyperplasia/hypertrophy, alveolar type II cells | ± | 0 | 0 | 0 | 1 |
| + | 0 | 0 | 0 | 1 | |
| Aggregation, alveolar macrophages | ± | 0 | 6 | 3 | 1 |
| + | 0 | 0 | 1 | 1 | |
| ++ | 0 | 0 | 1 | 0 | |
| Infiltration, inflammatory cells, alveolar/perivascular | ± | 3 | 1 | 2 | 2 |
| + | 0 | 0 | 1 | 1 | |
| +++ | 0 | 0 | 0 | 1 | |
| Lymph node, hilar | |||||
| Aggregation, macrophages | ± | 0 | 0 | 1 | 0 |
| + | 0 | 0 | 1 | 0 | |
| ++ | 0 | 0 | 0 | 3 | |
| +++ | 0 | 0 | 0 | 1 | |
Grade: ±, minimal; +, mild; ++, moderate; and +++, marked.