FIGURE 2.

TIMP-1 and -2 secretion by M. tuberculosis–infected and CoMtb-stimulated monocytes adherent to type I collagen. Monocytes adherent to type I collagen, fibronectin or in the absence of matrix were either infected with M. tuberculosis (MOI = 1) or stimulated with CoMtb (1:5 dilution). Supernatants were collected at 24 h postinfection and analyzed for secreted concentrations of (A) TIMP-1 and (B) TIMP-2 with M. tuberculosis–infected monocytes, and (C) TIMP-1 and (D) TIMP-2 secretion of CoMtb-stimulated monocytes. CoMCont was used as control of CoMtb. Bars show mean ± SD and data are representative of three independent experiments performed in triplicate. ***p < 0.001, ****p < 0.001. ns, not significant.