Table 1.
Invasive Pressure‐Volume Loop Assessment of Cardiac Function in Iron‐Overloaded WT Male and Female Mice
| WT‐Male Placebo | WT‐Male Iron | WT‐Female Placebo | WT‐Female Iron | WT‐Female OVX‐Placebo | WT‐Female OVX‐Iron | |
|---|---|---|---|---|---|---|
| n | 8 | 12 | 12 | 12 | 8 | 10 |
| HR, bpm | 512±18 | 390±24a | 508±22 | 503±24 | 469±27 | 407±30 |
| LVEDP, mm Hg | 2.9±0.4 | 12.9±0.9a | 3.1±0.4 | 5.3±0.9 | 4.5±0.9 | 12.7±1.3a |
| LVESP, mm Hg | 94±6.2 | 97±2.1 | 96±2.6 | 98±1.9 | 94±4.5 | 84±3.1 |
| LVEDV, μL | 24.8±1.1 | 26.0±3.0 | 26.3±0.9 | 26.8±4.1 | 27.5±2.0 | 34.6±4.5 |
| LVESV, μL | 6.8±0.9 | 7.1±0.9 | 6.9±0.9 | 6.8±0.7 | 4.8±1.3 | 15.2±0.9 |
| SV, μL | 19.9±1.7 | 20.8±0.7 | 20.3±1.5 | 19.2±2.5 | 22.7±2.7 | 19.3±1.8a |
| EF, % | 80.2±3.6 | 80±3.1 | 77.2±3.9 | 71.7±4.9 | 84.8±3.2 | 55.7±5.1b |
| dP/dtmax, mm Hg/s | 8781±86 | 8538±232 | 8612±279 | 8612±279 | 8764±187 | 7923±322 |
| SW, mJ | 0.29±0.038 | 0.28±0.024 | 0.31±0.021 | 0.29±0.059 | 0.25±0.02 | 0.24±0.025 |
| PRSW, mJ/μL | 0.012±0.35 | 0.011±0.008 | 0.012±0.023 | 0.011±0.006 | 0.009±0.005 | 0.006±0.005 |
| dP/dtmax/EDV, mm Hg/s per μL | 358±17 | 351±12 | 349±24 | 353±26 | 328±15 | 253±29b |
| ESPVR, mm Hg/μL | 3.3±0.6 | 3.6±0.5 | 3.4±0.25 | 3.5±0.4 | 3.7±0.3 | 2.4±0.6b |
| τ (Glantz), ms | 8.3±0.4 | 12.0±0.4a | 7.1±1.2 | 8.8±0.5 | 9.8±0.9 | 12.2±0.7b |
| EDPVR, mm Hg/μL | 0.101±0.038 | 0.131±0.090a | 0.105±0.016 | 0.109±0.012 | 0.118±0.01 | 0.141±0.023a |
dP/dt indicates rate of change in LV pressure; dP/dtmax/EDV, Starling contractile index; EDPVR, end‐diastolic pressure‐volume relationship; EF, ejection fraction; ESPVR, end‐systolic pressure‐volume relationship; HR, heart rate; LVEDP, end‐diastolic pressure; LVEDV, end‐diastolic volume; LVESP, end‐systolic pressure; LVESV, end‐systolic volume; OVX, ovariectomized; PRSW, preload‐recruitable stroke work; PV, pressure‐volume; SV, stroke volume; SW, stroke work; WT, wild‐type; τ, LV relaxation time constant.
a
P<0.05 for effect of iron.
b
P<0.05 for interaction.