Table 2.
Invasive Pressure‐Volume Loop Assessment of Cardiac Function in Iron‐Overloaded HJVKO Male and Female Mice
| HJVKO Male‐P | HJVKO Male‐Fe | HJVKO Female‐P | HJVKO Female‐Fe | HJVKO Female‐OVX‐P | HJVKO Female‐OVX‐Fe | |
|---|---|---|---|---|---|---|
| n | 8 | 12 | 12 | 8 | 8 | 12 |
| HR, bpm | 431±8 | 426±9a | 471±18 | 467±32a | 409±25 | 372±12 |
| LVEDP, mm Hg | 9.9±1.5 | 17.±2.0a | 8.9±0.8 | 10.1±1.1 | 6.3±0.8 | 10.5±1.8b |
| LVESP, mm Hg | 103±6.1 | 107.±7.4 | 93±2.5 | 91±3.4 | 96±4.3 | 98±4.3 |
| LVEDV, μL | 22.5±2.8 | 24.7±2.6 | 26.7±4.4 | 28.6±3.8 | 44.7±7.0 | 65.5±7.3 |
| LVESV, μL | 4.36±1.72 | 4.7±1.38 | 6.1±1.1 | 5.8±0.9 | 12.2±3.2 | 34.1±1.5 |
| SV, μL | 18.2±1.7 | 20±1.9 | 21±3.7 | 20±2.5 | 32.5±4.4 | 31.4±3.9 |
| EF, % | 80.8±2.9 | 80.9±3.4 | 78.7±3.1 | 70±2.8 | 72.7±4.2 | 51.9±4.3b |
| dP/dtmax, mm Hg/s | 9637±135 | 9201±149 | 8447±145 | 8367±128 | 9263±776 | 7089±477 |
| SW, mJ | 0.341±0.062 | 0.382±0.049 | 0.291±0.009 | 0.303±0.008 | 0.558±0.07 | 0.440±0.016 |
| dP/dtmax/EDV, mm Hg/s per μL | 428±31 | 372±45 | 317±33 | 290±34 | 207±21 | 123±23b |
| ESPVR, mm Hg/μL | 3.14±0.35 | 3.08±0.29 | 3.53±0.39 | 3.55±0.36 | 3.48±1.1 | 2.01±0.34b |
| τ (Glantz), ms | 9.23±0.41 | 13.7±0.32a | 9.29±1.1 | 9.87±0.66 | 10.7±0.72 | 12.73±1.3b |
| EDPVR, mm Hg/μL | 0.103±0.093 | 0.127±0.011a | 0.095±0.009 | 0.091±0.014 | 0.110±0.04 | 0.147±0.004b |
dP/dt indicates rate of change in LV pressure; dP/dtmax/EDV, Starling contractile index; EDPVR, end‐diastolic pressure‐volume relationship; EF, ejection fraction; ESPVR, end‐systolic pressure‐volume relationship; HR, heart rate; HJVKO, hemojuvelin‐null; LVEDP, LV end‐diastolic pressure; LVEDV, LV end‐diastolic volume; LVESP, LV end‐systolic pressure; LVESV, LV end‐systolic volume; PRSW, preload‐recruitable stroke work; SV, stroke volume; SW, stroke work; τ, LV relaxation time constant.
a
P<0.05 for effect of iron.
b
P<0.05 for interaction.