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. 2017 Jan 6;6(1):e004387. doi: 10.1161/JAHA.116.004387

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Wls deficiency in cardiac macrophages increases cardiac M2 to M1 ratio 4 days after MI. Flow cytometry analysis of mouse hearts for macrophage (F4/80), M1 (CD86) and M2 (CD206) percentages, 4 days after MI. A and B, No difference in total macrophage (A) or M1 (B) percentage after MI between cfms‐icre;Wls ^fl/fl and Wls ^fl/fl mice. C, A shift toward M2 in cfms‐icre;Wls ^fl/fl mice. D, Increased M2 to M1 ratio in cfms‐icre;Wls ^fl/fl hearts after MI (n=8 in cfms‐icre;Wls ^fl/fl, n=5 in Wls ^fl/fl group). Results are presented as mean±SEM. Statistical analysis: 2‐tailed unpaired Student t test. *P<0.05 vs Wls ^fl/fl. Cfms indicates colony‐stimulating factor 1 receptor; MI, myocardial infarction; Wls, Wntless.