Table 1.
Baseline Demographics and Patient Characteristics by History of PAD
| Variable | PAD (n=884) | No PAD (n=17 096) | P Value |
|---|---|---|---|
| Age, y, median (25th, 75th) | 73 (66.5, 79) | 70 (62, 76) | <0.0001 |
| Female sex | 251/884 (28.4) | 6090/17 096 (35.6) | <0.0001 |
| Region | <0.0001 | ||
| North America | 307/884 (34.7) | 4133/17 096 (24.2) | |
| Latin America | 138/884 (15.6) | 3299/17 096 (19.3) | |
| Europe | 368/884 (41.6) | 6893/17 096 (40.3) | |
| Asia Pacific | 71/884 (8.0) | 2771/17 096 (16.2) | |
| CHADS2 score, mean±SD | 2.66±1.25 | 2.09±1.09 | <0.0001 |
| ≤1 | 164/884 (18.6) | 5929/17 096 (34.7) | |
| 2 | 284/884 (32.1) | 6152/17 096 (36.0) | |
| ≥3 | 436/884 (49.3) | 5015/17 096 (29.3) | |
| Presenting characteristics | |||
| Systolic BP, mm Hg, median (25th, 75th) | 130 (120, 140) | 130 (120, 140) | 0.2785 |
| Weight, kg, median (25th, 75th) | 83.0 (71.5, 95.8) | 82.0 (70.0, 95.5) | 0.1417 |
| Moderate or severe renal impairment | 228/884 (25.8) | 2745/17 021 (16.1) | <0.0001 |
| Baseline comorbidities | |||
| History of stroke, TIA, or systemic embolism | 295/884 (33.4) | 3189/17 096 (18.7) | <0.0001 |
| Carotid disease (bruit, stent, stenosis, endarterectomy) | 169/884 (19.1) | 441/17 096 (2.6) | <0.0001 |
| Nonparoxysmal AF type | 745/884 (84.3) | 14 470/17 093 (84.7) | 0.7609 |
| Prior warfarin/VKA | 553/884 (62.6) | 9721/17 096 (56.9) | 0.0008 |
| Coronary artery disease | 523/884 (59.2) | 5469/17 092 (32.0) | <0.0001 |
| Myocardial infarction | 257/884 (29.1) | 2297/17 094 (13.4) | <0.0001 |
| CHF within 3 months or LVEF ≤40% | 363/884 (41.1) | 6000/17 096 (35.1) | 0.0003 |
| Diabetes mellitus | 325/884 (36.8) | 4172/17 096 (24.4) | <0.0001 |
| Hypertension | 813/884 (92.0) | 14 991/17 096 (87.7) | 0.0001 |
| Current smoking | 89/884 (10.1) | 1378/17 079 (8.1) | 0.0343 |
| Moderate or worse valvular heart disease | 239/884 (27.0) | 2953/17 094 (17.3) | <0.0001 |
| History of bleeding | 213/884 (24.1) | 2794/17 093 (16.3) | <0.0001 |
| History of fall within previous year | 77/828 (9.3) | 669/15 451 (4.3) | <0.0001 |
| Medications | |||
| ACEI or ARB | 668/877 (76.2) | 12 053/16 817 (71.7) | 0.0039 |
| Beta blocker | 603/877 (68.8) | 10 767/16 817 (64.0) | 0.0044 |
| Aspirin | 345/884 (39.0) | 5231/17 096 (30.6) | <0.0001 |
| Clopidogrel | 33/884 (3.7) | 300/17 096 (1.8) | <0.0001 |
ACEI indicates angiotensin‐converting enzyme inhibitor; AF, atrial fibrillation; ARB, angiotensin receptor blocker; BP, blood pressure; CHF, congestive heart failure; LVEF, left ventricular ejection fraction; PAD, peripheral artery disease; TIA, transient ischemic attack; VKA, vitamin K antagonist.