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. 2017 Jan 24;6(1):e004968. doi: 10.1161/JAHA.116.004968

Figure 7.

Figure 7

Loss of TBRII alters aortic medial gene expression in MFS mice. mRNA was purified from aortic media of 8‐week‐old mice, 2 weeks after treatment with tamoxifen. Groups included Acta2‐Cre0/0 Fbn1 +/+ mice (WT); Acta2‐Cre0/0 Fbn1 C1039G/+ mice [MFS(T)], or Acta2‐Cre+/0 Fbn1 C1039G/+ mice (MFS‐TBRII −/−). All mice were Tgfbr2 flox/flox. Gene expression was measured by qRT‐PCR, with normalization to 18S rRNA. Data are mean±SEM; n=8 to 12 per group; t tests with Bonferroni correction; † P<0.05; †† P<0.01; ††† P<0.001 for comparison of MFS‐TBRII −/− and MFS(T) mice. AU indicates arbitrary units; MFS, Marfan syndrome; (T), tamoxifen; TBRII, type II TGF‐β receptor; WT, wild‐type.