Table 1.
Infectious, autoimmune, and oncological complications in 35 patients with Nijmegen breakage syndrome.
| Symptoms | Number of patients | Age of manifestation, years, median (min–max) | Cause of death |
|---|---|---|---|
| Infections | |||
| No/mild | 17 | 5.8 (1–11) | |
| Severe | 18 | 7.1 (2–17) | 3 |
| Autoimmune complications | |||
| Arthritis | 1 | 14 | |
| Thyroiditis | 2 | 10 (6–14) | |
| Skin granulomas | 5 | 9.4 (4–13) | |
| Interstitial lymphocytic lung disease | 4 | 9.75 (6–13) | |
| Malignancies | |||
| B cell lymphoma | 10 | 8.7 (5–13) | |
| T cell lymphoma | 4 | 9.5 (4–18) | 3 |
| Acute lymphoblastic leukemia | 7 | 7.0 (2–12) | 1 |
| T-prolymphocytic leukemia | 1 | 6 | |
| Ganglioglioma | 1 | 15 | 1 |
| Other | |||
| Lymphomatoid granulomatosis | 3 | 13 (8–17) | |