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. 2017 Feb 3;6(2):e004161. doi: 10.1161/JAHA.116.004161

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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TG2 participates in collagen assembly. A, Collagen assembly was delayed in TG2−/− smooth muscle cells (SMCs; panels III, IV) when compared with that of WT SMCs (I, II). Adenoviral delivery of TG2 to TG2−/− SMCs (panels V, VI) recapitulated the WT time course for collagen assembly. Cell‐free samples did not show any assembled collagen fibers (panels VII, VIII). Images are representative of 6 independent experiments. B, Representative Western blot showing TG2 and α‐actin expression at days 1 and 3. TG2 indicates tissue transglutaminase; WT, wild type.