Table 2.
Exercise Performance by Tertile of Baseline ST2 Levels
| Low ST2 Tertile (n=58) | Mid ST2 Tertile (n=58) | High ST2 Tertile (n=58) | P Value | P Valuea | |
|---|---|---|---|---|---|
| Peak VO2, mL/kg per minute | 12.1 (10.9–14.4) | 11.9 (10.8–15.1) | 11.2 (10.0–13.3) | 0.12 | 0.017 |
| Peak VO2, % predicted | 44 (38–51) | 42 (35–48) | 39 (32–47) | 0.024 | 0.017 |
| Respiratory exchange ratio | 1.11 (1.05–1.17) | 1.09 (1.03–1.15) | 1.09 (1.02–1.15) | 0.41 | 0.41 |
| Peak systolic BP, mm Hg | 160 (140–184) | 154 (138–168) | 148 (126–168) | 0.07 | 0.005 |
| Rest HR, bpm | 67 (59–76) | 70 (60–75) | 69 (61–79) | 0.58 | 0.43 |
| Peak HR, bpm | 111 (96–136) | 107 (91–120) | 107 (91–128) | 0.12 | 0.07 |
| Chronotropic index | 0.55 (0.38–0.71) | 0.47 (0.29–0.62) | 0.49 (0.28–0.69) | 0.15 | 0.08 |
| VE/VCO2 slope | 31.7 (28.1–36.9) | 33.8 (28.6–37.5) | 34.9 (31.0–39.9) | 0.06 | 0.20 |
| 6‐minute walk distance, m | 351 (265–434) | 305 (244–372) | 311 (230–360) | 0.046 | 0.012 |
Total sample size with data (N=168–174). BP indicates blood pressure; bpm, beats per minute; HR, heart rate; ST2, suppression of tumorigenicity 2; VE/VCO2, ventilatory efficiency; VO2, oxygen consumption.
a
Adjusted for sex.