Skip to main content
. 2017 Feb 20;6(2):e004690. doi: 10.1161/JAHA.116.004690

Figure 2.

Figure 2

Development of atherosclerosis resulted from DKK3 deficiency. A, En face Oil Red O staining of aortas from DKK3−/−ApoE−/− mice and control mice fed NC or a HFD. Lesion occupation was quantified and shown in the right and bottom panel. n=15 to 18. B, Hematoxylin and eosin staining of the lesions in aortic root sections. Scale bar=500 μm, n=8 to 10. C, Brachiocephalic artery sections were stained with hematoxylin and eosin. Scale bar=100 μm, n=11 to 12. D and E, Body weight, triglycerides, total cholesterol, and lipoprotein profiles from DKK3−/−ApoE−/− and ApoE−/− mice fed a HFD. n=20. *P<0.05 in A through C. DKK3 indicates Dickkopf‐3; HDL, high‐density lipoprotein; HFD, high‐fat diet; IDL, intermediate‐density lipoprotein; LDL, low‐density lipoprotein; NC, normal chow; TC, total cholesterol; TG, triglyceride; VLDL, very‐low‐density lipoprotein.