Figure 4.

Atherogenesis of ApoE^−/− mice transplanted with DKK3 deficient bone marrow cells. A and B, The genotype of ApoE (A) and DKK3 (B) in genomic DNA isolated from circulating white blood cells of recipient animals transplanted with DKK3^−/−ApoE^−/− or ApoE^−/− bone marrow. n=4. C, Representative aorta stained with Oil Red O (n=10) (left panel) and quantification of plaque occupation in mice that received bone marrow cells from DKK3^−/−ApoE^−/− or ApoE^−/− mice. D, Aortic root sections stained with hematoxylin and eosin (n=10) and quantification of plaque area. *P<0.05 in (C and D). DKK3 indicates Dickkopf‐3.