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. 2017 Feb 9;6(2):e004923. doi: 10.1161/JAHA.116.004923

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Scatterplots of Lp‐PLA2 plasma activity levels, BMI z‐score, obstructive apnea hypopnea index (AHI), and T_max in children with and without obesity or OSA. A, T_max vs BMI z‐score: r=0.319, P<0.001. B, Lp‐PLA2 vs BMI z‐score: r=0.350, P<0.001. C, T_max vs AHI: r=0.489, P<0.001. D, Lp‐PLA2 vs AHI: r=0.483, P<0.001. E, AHI vs BMI z‐score, not significant. F, Lp‐PLA2 vs T_max: r=0.837, P<0.001. Actual values rather than log‐transformed values were used in the linear fitting functions shown. AHI is displayed as log scale (C and D). Dotted lines indicate the cutoff used to define endothelial dysfunction, ie, T_max >45 seconds. AHI indicates apnea hypopnea index; BMI, body mass index; Lp‐PLA ₂, lipoprotein‐associated phospholipase A2; T_max, time to peak reperfusion; TST, total sleep time.