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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Psychoneuroendocrinology. 2017 May 18;82:107–116. doi: 10.1016/j.psyneuen.2017.05.016

Figure 5. a-b) ERβ disruption upregulates 5-HT2A but has no effect on 5-HT1A in female rat hippocampus.

Figure 5

ERβ regulation of serotonergic receptors, 5-HT1A and 5-HT2A, was examined in the hippocampus of ERβ mutant female rats. Data indicate that ERβ mutant rats with deletions of exon 3 or exon 4 leads to an increase in 5-HT2A protein expression but has no effect on 5-HT1A in the hippocampus of both 6 and 10-month-old rats. c-d) TrkB activation downregulates 5-HT2A in primary hippocampal neurons. Interaction between BDNF/TrkB and 5-HT2A signling was examined in primary hippocampal neurons. Data indicate that: c) Activation of BDNF/TrkB negatively regulates 5-HT2A; d) Activation of 5-HT2A does not regulate BDNF/TrkB. Data are shown as mean ± standard deviation, n=3. *p<0.05, **p <0.01, ***p <0.001.