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. Author manuscript; available in PMC: 2018 Jul 15.
Published in final edited form as: Bioorg Med Chem Lett. 2017 May 15;27(14):3111–3116. doi: 10.1016/j.bmcl.2017.05.045

Figure 1.

Figure 1

SPOT synthesis and PIPE principles. (A): General concept of the SPOT synthesis. (B): Key steps of the process of inverted peptides. (a): coupling of the bromoacetyl moiety (1 M in DMF, 4-time coupling, 15 min reaction each), (b): selective cysteine detritylation with TFA (7% in DCM), (c): macrocycle formation, (d): one-pot acid cleavage and side chain deprotection (60% TFA followed by 90% TFA).