Table 3.

Results from the three-way ANOVA of clock gene expression in the frontal cortex of 6-month and 18-month-old Non-Tg and 3×Tg-AD mice after a 12 h D/L cycle (n = 12 per group). D, darkness; L, light; G, genotype; A, age; F, Fisher’s test. ^*p < 0.05; ^**p < 0.01; ^***p < 0.001

		D/L	G	A	D/L×G	D/L×A	G×A	D/L×G×A
Bmal1	F	11.40**	0.02	12.84**	0.29	5.58*	0.45	1.17
Clock	F	1.95	0.01	6.92*	0.22	4.23*	0.51	0.01
Cry1	F	0.02	0.03	26.46***	0.18	5.24*	0.02	0.37
Cry2	F	1.88	0.08	16.64**	0.15	4.71*	0.02	0.14
Per1	F	1.70	0.45	7.06*	0.02	3.68	0.01	0.13
Per2	F	0.28	1.47	19.50***	0.62	2.81	0.59	0.31
Per3	F	0.88	1.43	17.23**	0.04	4.97*	0.01	0.17
Nr1d1	F	0.27	0.38	16.77**	0.69	0.52	0.03	0.98
Rorα	F	2.59	1.81	4.72*	0.25	2.27	0.23	0.27
Csnk1ɛ	F	2.60	0.88	22.45***	0.07	3.79	0.01	0.13
Sirt1	F	2.04	0.85	1.61	0.00	2.76	0.37	0.93