Table 2.
ARIC visit 1 Lp(a) quintiles hazard ratios (95% CI) for incident heart failure hospitalization (prevalent MI included).
| Lp(a) [HF/at risk] | Hazard ratio (95% confidence interval) | p trend | ||||
|---|---|---|---|---|---|---|
| Quintile 1 (0.02–2.41) [479/2943 (16%)] |
Quintile 2 (2.54–5.59) [447/2742 (16%)] |
Quintile 3 (5.73–11.29) [502/2815 (18%)] |
Quintile 4 (11.43–22.96) [583/2825 (21%)] |
Quintile 5 (23.10–108.23) [594/2829 (21%)] |
||
| Model 1 | reference | 0.96 (0.84–1.09) |
1.01 (0.89–1.14) |
1.14 (1.00–1.29) |
1.14 (1.00–1.29) |
0.02 |
| Model 2 | reference | 1.03 (0.90–1.17) |
1.09 (0.95–1.23) |
1.21 (1.06–1.37) |
1.23 (1.08–1.40) |
0.004 |
| Model 3 | reference | 1.02 (0.90–1.17) |
1.09 (0.96–1.24) |
1.21 (1.07–1.38) |
1.24 (1.09–1.41) |
0.002 |
| Model 4 | reference | 1.04 (0.91–1.19) |
1.10 (0.96–1.25) |
1.22 (1.07–1.38) |
1.19 (1.05–1.36) |
0.01 |
| Model 5 | reference | 1.05 (0.92, 1.20) |
1.09 (0.96, 1.25) |
1.21 (1.06, 1.37) |
1.16 (1.01, 1.33) |
0.049 |
| Model 6 | reference | 1.05 (0.92, 1.20) |
1.09 (0.96, 1.25) |
1.21 (1.06, 1.38) |
1.16 (1.02, 1.34) |
0.037 |
Follow-up to December 31, 2012; mean follow-up 20.0±6.55 years, median follow-up 23.4 (16.8, 24.5) years. Lp(a) presented as mg/dL. P trend tests a linear increase in log relative hazard with increasing quintiles.
Model 1: adjusted by age, gender, and race.
Model 2: model 1 plus systolic blood pressure, hypertension, diabetes, current smoking, BMI, and heart rate.
Model 3: model 2 plus HDL-C.
Model 4: model 3 plus prevalent CHD.
Model 5: model 4 plus LDL-C
Model 6: model 4 plus Lp(a)- cholesterol corrected LDL-C
HF, incident heart failure hospitalization.