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Synthesis of compounds 4 by coupling and reduction. Reagents and conditions: a. anhydrides or NHS ester 8, DMF, 110 °C, 3 h; b. 1) POCl3, DIPEA, 1,4-dioxane, 70-90 °C, overnight (for 4b-4f) or r.t., 4 h (for 4a); 2) PdCl2(dppf)•DCM, NaBH4, TMEDA, THF, r.t., 16-48 h. cLogP values for 4a-4f were calculated from ChemBioDraw Ultra 12.0.
