Table 3.

Serum biochemical levels after treatment with different formulations

Formulation	AST (U/L)	ALT (U/L)	CRE	BUN
Negative control	15.26±0.405	27.89±5.51	22.10±6.63	11.44±2.38
PTX injection (4 mg/kg, iv)	16.92±0.484*	36.96±8.54	21.47±5.09	5.96±1.92*
ACGs-NSps (0.4 mg/kg, iv)	18.84±0.228***	33.89±8.38	22.57±6.26	4.83±1.45*
FA-ACGs-NSps (0.4 mg/kg, iv)	16.45±0.594	27.71±8.04	18.54±5.76	9.36±2.01

Notes: Results are presented as mean ± SD, n=10.

^*P<0.05,

^***P<0.001 versus normal saline.

Abbreviations: AST, aspartate transaminase; ALT, alanine aminotransferase; CRE, creatinine; BUN, blood urea nitrogen; PTX, paclitaxel; ACGs-NSps, Annonaceous acetogenins nanosuspensions; FA-ACGs-NSps, folic acid-modified ACGs-NSps; iv, intravenous; SD, standard deviation.