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PROMISE identified more SNPs with a RegulomeDB score of 1 than single phenotype analyses (p = 1.22 × 10−6). Results shown for PR14 (see Methods for details). Cumulative number of SNPs with a RegulomeDB score of 1 for each analysis (PROMISE, red; ON, blue; thrombosis, pink; CNS toxicity, yellow. See Supplemental Digital Content Text for statistical details.
