The A allele of F2RL1 rs2243057 is associated with pleotropic phenotypic effects phenotypes. A, Cumulative incidence of osteonecrosis (ON) plotted by rs2243057 genotype. B, Percentage of patients with thrombosis by rs2243057 genotype. Numbers above the column indicate cases over total number of patients with the indicated genotype. C, Change in serum triglycerides (TG) from week 7 to week 8 by rs2243057 genotype. D, Change in serum cholesterol (Chol) from week 7 to week 8 by rs2243057 genotype. E, Week 7 serum albumin by rs2243057 genotype in low risk patients. F, Week 7 serum albumin by rs2243057 genotype in standard/high risk (Std/high) patients. Mean is indicated by dark horizontal line, whiskers indicate 95% confidence interval, squares indicate raw data.