Table 1.

Top 10 SNPs associated with pleotropic glucocorticoid effects ranked by PROMISE PR14 p-value.

PR rank	SNP	Ch	Gene	Location	Alleles	MAF	RDB score	PR14 p-value	PR14 stat	ON p-value	ON stat
1	rs4703882	5	ATP6AP1L(dist=100900)	intergenic	A/T	17.05%	3a	2.54×10−7	0.084	0.019	0.115
2	rs381518	12	KRT75	upstream	C/A	37.63%	5	2.01×10−6	0.078	0.109	0.078
3	rs3743712	16	TK2	UTR3	A/G	9.82%	1f	2.30×10−6	0.072	0.167	0.064
4	rs401926	12	KRT75	SYN	G/A	37.94%	4	2.74×10−6	0.077	0.122	0.075
5	rs7743593	6	SLC16A10	DS	T/C	22.95%	6	8.79×10−6	0.071	0.021	0.115
6	rs10869729	9	PCSK5	UTR3	T/C	10.27%	No Data	9.76×10−6	0.069	0.003	0.141
7	rs298109	12	KRT75	NS	C/T	38.26%	5	1.17×10−5	0.073	0.125	0.077
8	rs13218329	6	KIF25-AS1	DS	A/G	14.57%	5	1.26×10−5	0.071	0.038	0.100
9	rs4107159	12	KIF25-AS1(dist=5019)	intergenic	G/A	49.10%	6	1.46×10−5	0.072	0.010	0.124
10	rs298120	12	KRT6A	intronic	C/T	39.44%	5	1.67×10−5	0.070	0.106	0.078

PR14, main PROMISE analysis (see Methods for details). Ch, chromosome. UTR3, 3′ untranslated region. SYN, synonymous. NS, nonsynonymous. The major and minor alleles are listed in the Alleles column, (major is first, minor is second, and risk allele is in bold). MAF, minor allele frequency. Stat, statistic (effect size) for the minor allele. A negative statistic means the minor allele is associated with less ON, while a positive statistic means the minor allele is associated with more ON. ON, osteonecrosis. RDB, RegulomeDB.