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. 2017 Mar 6;6(3):e004158. doi: 10.1161/JAHA.116.004158

Table 3.

Preeclampsia and Risk of Subsequent Major Coronary Events Among 342 421 Norwegian Women With 1 to 5 Singleton Deliveries and a First Delivery During 1980–2002, Followed From the Age of 40

No./Events Unadjusted Adjusteda
HR (95% CI) P Value HR (95% CI) P Value
All women (N=342 421)
No preeclampsia 323 323/857 1 ··· 1 ···
Preeclampsia only 12 592/64 2.05 (1.59–2.65) <0.001 2.02 (1.56–2.60) <0.001
Preeclampsia+SGA and/or preterm deliveryb 6506/59 3.76 (2.88–4.89) <0.001 3.63 (2.79–4.72) <0.001
One lifetime pregnancy (n=61 352)
No preeclampsia 58 520/292 1 ··· 1 ···
Preeclampsia only 1663/19 2.36 (1.47–3.76) <0.001 2.26 (1.42–3.60) 0.001
Preeclampsia+SGA and/or preterm delivery 1169/19 3.56 (2.24–5.66) <0.001 3.32 (2.09–5.29) <0.001
More than 1 lifetime pregnancy (n=281 069)
No preeclampsia 264 803/565 1 ··· 1 ···
Preeclampsia complicating any pregnancyc
Preeclampsia only 10 929/45 2.02 (1.49–2.73) <0.001 1.97 (1.45–2.67) <0.001
Preeclampsia+SGA and/or preterm delivery 5337/40 3.85 (2.79–5.31) <0.001 3.75 (2.72–5.17) <0.001
Preeclampsia complicating first pregnancy only
Preeclampsia only 6318/25 1.98 (1.33–2.96) 0.001 1.95 (1.31–2.91) 0.001
Preeclampsia+SGA and/or preterm delivery 2881/16 2.94 (1.79–4.83) <0.001 2.81 (1.70–4.61) <0.001
Preeclampsia complicating first and second pregnancies
Preeclampsia only 937/5 2.31 (0.96–5.58) 0.062 2.20 (0.91–5.32) 0.079
Preeclampsia+SGA and/or preterm delivery 826/8 4.43 (2.21–8.91) <0.001 4.66 (2.31–9.37) <0.001
Preeclampsia complicating second or later pregnancies
Preeclampsia only 3674/15 1.98 (1.19–3.31) 0.009 1.93 (1.16–3.23) 0.012
Preeclampsia+SGA and/or preterm delivery 1630/16 5.11 (3.11–8.39) <0.001 4.92 (2.99–8.10) <0.001

Cox regression analyses stratified by parity. HR indicates hazard ratio; SGA, small for gestational age (<10th percentile).

a

Adjusted for education, marital status and birth year of first child.

b

Preterm delivery (<37 weeks of gestation), SGA, or both.

c

The first time preeclampsia occurred, independent of which pregnancy.