Table 3.

Preeclampsia and Risk of Subsequent Major Coronary Events Among 342 421 Norwegian Women With 1 to 5 Singleton Deliveries and a First Delivery During 1980–2002, Followed From the Age of 40

	No./Events	Unadjusted		Adjusteda
		HR (95% CI)	P Value	HR (95% CI)	P Value
All women (N=342 421)
No preeclampsia	323 323/857	1	···	1	···
Preeclampsia only	12 592/64	2.05 (1.59–2.65)	<0.001	2.02 (1.56–2.60)	<0.001
Preeclampsia+SGA and/or preterm deliveryb	6506/59	3.76 (2.88–4.89)	<0.001	3.63 (2.79–4.72)	<0.001
One lifetime pregnancy (n=61 352)
No preeclampsia	58 520/292	1	···	1	···
Preeclampsia only	1663/19	2.36 (1.47–3.76)	<0.001	2.26 (1.42–3.60)	0.001
Preeclampsia+SGA and/or preterm delivery	1169/19	3.56 (2.24–5.66)	<0.001	3.32 (2.09–5.29)	<0.001
More than 1 lifetime pregnancy (n=281 069)
No preeclampsia	264 803/565	1	···	1	···
Preeclampsia complicating any pregnancyc
Preeclampsia only	10 929/45	2.02 (1.49–2.73)	<0.001	1.97 (1.45–2.67)	<0.001
Preeclampsia+SGA and/or preterm delivery	5337/40	3.85 (2.79–5.31)	<0.001	3.75 (2.72–5.17)	<0.001
Preeclampsia complicating first pregnancy only
Preeclampsia only	6318/25	1.98 (1.33–2.96)	0.001	1.95 (1.31–2.91)	0.001
Preeclampsia+SGA and/or preterm delivery	2881/16	2.94 (1.79–4.83)	<0.001	2.81 (1.70–4.61)	<0.001
Preeclampsia complicating first and second pregnancies
Preeclampsia only	937/5	2.31 (0.96–5.58)	0.062	2.20 (0.91–5.32)	0.079
Preeclampsia+SGA and/or preterm delivery	826/8	4.43 (2.21–8.91)	<0.001	4.66 (2.31–9.37)	<0.001
Preeclampsia complicating second or later pregnancies
Preeclampsia only	3674/15	1.98 (1.19–3.31)	0.009	1.93 (1.16–3.23)	0.012
Preeclampsia+SGA and/or preterm delivery	1630/16	5.11 (3.11–8.39)	<0.001	4.92 (2.99–8.10)	<0.001

Cox regression analyses stratified by parity. HR indicates hazard ratio; SGA, small for gestational age (<10th percentile).

^aAdjusted for education, marital status and birth year of first child.

^bPreterm delivery (<37 weeks of gestation), SGA, or both.

^cThe first time preeclampsia occurred, independent of which pregnancy.