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. 2017 Feb 27;6(3):e004694. doi: 10.1161/JAHA.116.004694

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Effect of microRNA (miR)‐181‐sponge on mitochondrial function and cellular metabolism. A, Measurement of H₂O₂ production as an indicator of reactive oxygen species (ROS) generated from the miR‐181‐sponge and scrambled sponge H9c2 cell lines. B, Representative trace for the mitochondrial O₂ consumption rate (OCR). C, Analysis of OCR under basal and after addition of oligomycin, carbonilcyanide p‐triflouromethoxyphenylhydrazone (FCCP), iodoacetate, and rotenone/antimycin in miR‐181‐sponge compared to scramble‐expressed H9c2 cells. D, Representative trace for extracellular acidification rates (ECAR). E, Analysis of glycolysis using ECAR, in miR‐181‐sponge compared to scramble‐expressed H9c2 cells. *P<0.05 vs scramble (n=8).