Table 6.
Multivariable Logistic Regression of Factors Associated With the Composite Endpoint of ICH, Ischemic Stroke, MI, and Death (n=7738) for All Included Patients
| OR (95% CI) | P Value | |
|---|---|---|
| Renal function, mL/min per 1.73 m2 | ||
| eGFR ≥60 | 1.0 (ref) | |
| eGFR 45 to 59 | 1.32 (1.01–1.72) | 0.045 |
| eGFR 30 to 44 | 1.54 (1.09–2.18) | 0.025 |
| eGFR <30, or dialysis | 1.70 (1.06–2.72) | 0.27 |
| TTR | ||
| TTR >75% | 1.0 (ref) | |
| TTR 60% to 75% | 1.84 (1.41–2.40) | <0.001 |
| TTR <60% | 2.09 (1.59–2.74) | <0.001 |
| Age, y | ||
| <65 | 1.0 (ref) | |
| 65 to 74 | 2.03 (1.41–2.92) | <0.001 |
| 75 to 84 | 3.40 (2.38–4.87) | <0.001 |
| ≥85 | 3.14 (2.02–4.89) | <0.001 |
| Female | 0.92 (0.74–1.14) | 0.427 |
| Diabetes mellitus | 1.08 (0.82–1.43) | 0.574 |
| Hypertension | 0.96 (0.77–1.21) | 0.740 |
| Vascular disease (past MI, ischemic heart disease, or peripheral arterial disease) | 1.40 (1.06–1.83) | 0.017 |
| Heart failure | 1.78 (1.33–2.36) | <0.001 |
| Valvular disease | 1.27 (0.59–2.75) | 0.542 |
| Cancer within last 3 years | 0.85 (0.62–1.15) | 0.292 |
| Coagulation/platelet defect | 3.06 (1.33–7.07) | 0.009 |
| Anemia | 1.10 (0.71–1.69) | 0.681 |
| Ischemic stroke | 0.71 (0.43–1.20) | 0.200 |
| Past systemic emboli | 1.70 (1.13–2.54) | 0.010 |
| Deep vein thrombosis/pulmonary embolism | 1.51 (1.05–2.16) | 0.025 |
| Past ICH | 1.12 (0.29–4.35) | 0.865 |
| Past gastrointestinal bleeding | 1.37 (0.70–2.68) | 0.356 |
| Antiplatelet therapy | 1.07 (0.85–1.35) | 0.543 |
| No. of INR measurements | 1.03 (1.02–1.04) | <0.001 |
| No. of days on warfarin | 1.00 (0.99–1.00) | <0.001 |
P values for the interaction terms for the outcome is presented below the table. Interaction terms tested: age and eGFR: P=0.398; age and TTR, P=0.721; eGFR and TTR, P=0.169. eGFR indicates estimated glomerular filtration rate; ICH, intractranial hemorrhage; INR, international normalized ratio; MI, myocardial infarction; TTR, time‐in‐therapeutic range.