Table 5.
Primary and Secondary Outcomes by Time‐Averaged SBP Levels During the Treatment Period
| Time‐Averaged SBP Category, mm Hg | Outcome, No. (%) | HR (95% CI) | Adjusteda HR (95% CI) |
|---|---|---|---|
| Primary outcome | |||
| First stroke | |||
| <120 | 3 (2.9) | 2.84 (0.85–9.43) | 3.43 (1.01–11.63) |
| 120 to <140b | 24 (1.1) | Ref | Ref |
| ≥140 | 25 (2.9) | 2.73 (1.56–4.77) | 2.58 (1.46–4.56) |
| Secondary outcomes | |||
| Composite of stroke, myocardial infarction, or death from cardiovascular causes | |||
| <120 | 4 (3.9) | 3.12 (1.10–8.87) | 3.80 (1.31–11.01) |
| 120 to <140 | 29 (1.3) | Ref | Ref |
| ≥140 | 28 (3.2) | 2.52 (1.50–4.24) | 2.37 (1.40–4.02) |
| All‐cause death | |||
| <120 | 5 (5.0) | 2.46 (0.98–6.18) | 3.41 (1.34–8.67) |
| 120 to <140 | 47 (2.1) | Ref | Ref |
| ≥140 | 35 (4.1) | 1.94 (1.25–3.01) | 1.63 (1.05–2.55) |
SBP indicates systolic blood pressure.
a
Adjusted for age, sex, study centers, methylenetetrahydrofolate reductase C677T polymorphism, study treatment groups, body mass index, smoking, alcohol drinking, systolic and diastolic blood pressure, estimated glomerular filtration rate, fasting glucose, total cholesterol, folate, vitamin B12, and homocysteine levels at baseline.
b
Versus ≥140 mm Hg; adjusted hazard ratio (HR), 0.39; 95% CI, 0.22–0.69.