Table 6.

Primary and Secondary Outcomes by Time‐Averaged DBP During the Treatment Period

Time‐Averaged DBP Category, mm Hg	Outcome, No. (%)	HR (95% CI)	Adjusteda HR (95% CI)
Primary outcome
First stroke
≥90	7 (2.7)	Ref	Ref
<90	45 (1.5)	0.56 (0.25–1.24)	0.41 (0.17–0.98)
80 to <90	23 (1.5)	0.56 (0.24–1.30)	0.45 (0.18–1.09)
75 to <80	10 (1.2)	0.41 (0.16–1.09)	0.29 (0.10–0.83)
<75	12 (2.2)	0.78 (0.31–1.99)	0.46 (0.14–1.50)
Secondary outcomes
Composite of stroke, myocardial infarction, or death from cardiovascular causes
≥90	8 (3.0)	Ref	Ref
<90	53 (1.8)	0.57 (0.27–1.20)	0.37 (0.16–0.84)
80 to <90	26 (1.7)	0.55 (0.25–1.21)	0.41 (0.18–0.94)
75 to <80	11 (1.3)	0.40 (0.16–0.99)	0.25 (0.09–0.69)
<75	16 (2.9)	0.90 (0.39–2.11)	0.49 (0.17–1.41)
All‐cause death
≥90	7 (2.7)	Ref	Ref
<90	80 (2.7)	0.98 (0.45–2.13)	0.66 (0.29–1.50)
80 to <90	35 (2.3)	0.85 (0.38–1.91)	0.69 (0.30–1.59)
75 to <80	24 (2.7)	0.98 (0.42–2.28)	0.60 (0.24–1.49)
<75	21 (3.8)	1.34 (0.57–3.17)	0.60 (0.22–1.61)

DBP indicates diastolic blood pressure; HR, hazard ratio.

^aAdjusted for age, sex, study centers, methylenetetrahydrofolate reductase C677T polymorphism, study treatment groups, body mass index, smoking, alcohol drinking, systolic and diastolic blood pressure, estimated glomerular filtration rate, fasting glucose, total cholesterol, folate, vitamin B12, and homocysteine levels at baseline.