Table 1.
Baseline Characteristics According to Self‐Reported Family History of CHD and GRS50 Categories
| Family History | GRS50 Score | ||||
|---|---|---|---|---|---|
| No (N=14 807) | Yes (N=8788) | Low (N=4719) | Intermediate (N=14 157) | High (N=4719) | |
| Age, y | 57.8 (7.7) | 58.4 (7.7) | 58.2 (7.8) | 58.0 (7.7) | 57.9 (7.7) |
| Men, n (%) | 5963 (40.3) | 3010 (34.3) | 1829 (38.8) | 5342 (37.7) | 1802 (38.2) |
| Body mass index, kg/m2 | 25.7 (4.0) | 25.8 (4.0) | 25.7 (4.0) | 25.7 (4.0) | 25.8 (4.0) |
| Systolic blood pressure, mm Hg | 140.5 (20.2) | 142.1 (20.0) | 140.8 (20.1) | 141.0 (20.1) | 141.8 (20.1) |
| Use of antihypertensives, n (%) | 2307 (15.6) | 1746 (19.9) | 825 (17.5) | 2417 (17.1) | 811 (17.2) |
| Apolipoprotein A‐I, g/L | 1.569 (0.281) | 1.574 (0.279) | 1.573 (0.279) | 1.571 (0.283) | 1.565 (0.275) |
| Apolipoprotein B, g/L | 1.059 (0.259) | 1.086 (0.262) | 1.051 (0.260) | 1.068 (0.261) | 1.089 (0.259) |
| Prevalent diabetes mellitus, n (%) | 566 (3.8) | 364 (4.1) | 178 (3.8) | 575 (4.1) | 177 (3.8) |
| Current smoker, n (%) | 4268 (28.8) | 2354 (26.8) | 1316 (27.9) | 3999 (28.2) | 1307 (27.7) |
| Self‐reported family history of CHD, n (%) | 0 (0.0) | 8788 (100.0) | 1552 (32.9) | 5314 (37.5) | 1922 (40.7) |
| GRS50 | −0.045 (0.99) | 0.075 (1.00) | −1.37 (0.42) | −0.02 (0.46) | 1.43 (0.50) |
| Incident CHD event, n (%) | 1215 (8.2) | 998 (11.4) | 318 (6.7) | 1303 (9.2) | 592 (12.5) |
| Median (mean) Follow‐up | 13.87 (14.45) | 13.65 (14.37) | 14.47 (13.97) | 14.41 (13.80) | 14.39 (13.56) |
| Incidence rate from CHD per 100 000 person‐years | 591.8 | 832.1 | 482.3 | 667.1 | 925.2 |
Data are presented as mean (SD) unless indicated. CHD indicates coronary heart disease; GRS50, 50‐variant genetic risk score.