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. 2017 Feb 27;6(3):e005394. doi: 10.1161/JAHA.116.005394

Figure 1.

Figure 1

Effect of mycophenolate mofetil (MMF) treatment on circulating B cells in mice with systemic lupus erythematosus (SLE) treated with MMF or vehicle. A, Representative histograms from SLE mice treated with vehicle or MMF. Peripheral blood leukocytes (PBLs) were isolated from mice at 27 weeks (0 weeks of MMF), 31 weeks (4 weeks of MMF), and 35 weeks (8 weeks of MMF) and stained with anti–mouse CD45R phycoerythrin–cyanine 7 (PE‐Cy7). Percentages of positive cells are indicated. B, Percentage of PBLs in vehicle‐ or MMF‐treated mice with staining for anti–mouse CD45R at the indicated time points. The percentage of CD45R+ cells was significantly lower in MMF‐treated animals after 4 weeks. *P<0.05 vs SLE mice treated with vehicle (27 weeks); # P<0.01 vs SLE mice treated with vehicle at 31 and 35 weeks and SLE mice treated with MMF at 27 and 35 weeks.