Table 2.
The Risk of Incident AF Was Significantly Lower in the Normalized Treated Group Compared With the Nonnormalized Treated and Untreated Groups
| Hazard Ratios for Atrial Fibrillation | |||
|---|---|---|---|
| HR | 95% CI | P Value | |
| Normalized treated vs untreated (reference) | |||
|
Univariate n=40 856 vs n=11 853 |
0.713 | 0.635–0.801 | <0.0001 |
|
Propensity matched (stabilized IPTW) n=40 857 vs n=11 853 |
0.792 | 0.702–0.893 | 0.0001 |
| Normalized treated vs nonnormalized treated (reference) | |||
|
Univariate n=40 856 vs n=23 930 |
0.800 | 0.727–0.880 | <0.0001 |
|
Propensity matched (stabilized IPTW) n=40 859 vs n=23 928 |
0.896 | 0.813–0.987 | 0.0255 |
| Nonnormalized treated vs untreated (reference) | |||
|
Univariate n=23 930 vs n=11 853 |
0.895 | 0.788–1.017 | 0.0881 |
|
Propensity matched (stabilized IPTW) n=23 930 vs n=11 855 |
0.888 | 0.782–1.009 | 0.0675 |
The risk was also lower in non‐normalized treated group compared to the untreated group but lacks statistical significance. AF indicates atrial fibrillation; HR, hazard ratio; IPTW, inverse probability of treatment weights.